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The thiazides may decrease serum PBI levels without signs of thyroid disturbance.

Patients receiving MAXZIDEtriamterene and hydrochlorothiazideshould be carefully monitored for fluid or electrolyte imbalancesi.ehyponatremiahypochloremic alkalosishypokalemia and hypomagnesemiaDetermination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervalsSerum and urine electrolyte determinations are especially important and should be frequently performed when the patient is vomiting or receiving parenteral fluidsWarning signs or symptoms of fluid and electrolyte imbalance includedryness of mouththirstweaknesslethargydrowsinessrestlessnessmuscle pains or crampsmuscular fatiguehypotensionoliguriatachycardia and gastrointestinal disturbances such as nausea and vomiting.

Take the missed dose as soon as you remember itHoweverif it is almost time for your next doseskip the missed dose and continue your regular dosing scheduleDo not take a double dose to make up for a missed one.

To reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

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