All the biologics seem to work equally well in combination with methotrexate.

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methotrexate in serum is approximately 50 protein bound.

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some patients taking methotrexate have headaches, dizzinesss, fatigue and mood changes, especially when first starting on methotrexate.

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if they do occur, the side effects of methotrexate are most likely to be minor and temporary.

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in high-dose methotrexate administration a temporary withdrawal of the ppi may be considered in some patients see drug interactions .

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